2021 AMI Online Salon

VEGF in Wet Age-Related Macular Degeneration

Project Details

  • Entrant Name:  Jim Perkins
  • Client: Opthea, Ltd.
  • Copyright: James A. Perkins, 2020
  • Medium/software used: Adobe Illustrator, UCSF Chimera
  • Final presentation format: Corporate annual report, prospectus, SEC S-1 filing
  • Primary Audience: Investors

Project Description

To demonstrate the structural changes in Wet Age-Related Macular Degeneration and the role of Vascular Endothelial Growth Factor (VEGF). Binding of VEGF to its receptors promotes the growth of new vessels, which extend past Bruch’s Membrane and the Retina Pigmented Epithelium (RPE) into the retina. Increased permeability results in the accumulation of fluid in Bruch’s Membrane (Drusen) and in the retina itself, distorting the photoreceptor layer.Subsequent illustrations (not included) demonstrate the client’s experimental drug, which blocks VEGF-A, -C, and -D. The illustrations will appear in the client’s annual report and prospectus, targeted to investors who generally have some background in biology and chemistry. Because the illustrations will also be used in the client’s S-1 filing with the Securities & Exchange Commission (which are always printed in black-and-white) all cells and other structures must be clearly differentiated by gray value as well as color.