2021 AMI Online Salon

SARS-CoV-2 Cytokine Storm

Project Details

  • Entrant Name:  Xian Boles
  • Client: N/A (course assignment at Rochester Institute of Technology)
  • Copyright: Xian Boles, 2021
  • Medium/software used: Adobe Photoshop and Illustrator, Chimera
  • Final presentation format: Instructional poster
  • Primary Audience: educated lay audience

Project Description

This piece is intended to instruct a disease process to an educated audience. Viewers will be able to identify the general mechanism of infection and pathogenesis of COVID-19, proteins involved in infection, mediators of human inflammatory response, and a drug used to target these pathways. Original image is formatted for print as 8.5″ x 11″, CMYK, 300ppi. Assignment requires the use of the Protein Data Bank and Chimera to obtain and render 3D models of proteins and molecules. Content must also include an illustration of a relevant anatomical structures and a patient suffering from the disease. The patient, ventilator, and organs were rendered in Adobe Photoshop. Text added with Adobe Illustrator. Technical goals include balancing a composition that simultaneously shows an easy-to-follow molecular mechanism and an affected patient. Challenges include superimposing organs onto a person using a ventilator and balancing attention drawn between the figure and the molecular mechanism.