2021 AMI Online Salon

Malignant Hyperthermia

Project Details

  • Entrant Name:  Emilyn Frohn
  • Client:Isabel Romero-Calvo
  • Copyright: Emilyn Frohn, 2021
  • Medium/software used:PDB, VMD, Pixologic ZBrush®, Autodesk 3ds Max®, tyFlow®, Redshift®, Adobe After Effects®, Adobe Illustrator®
  • Final presentation format:Poster, 12”x18”
  • Primary Audience:Biomedical professionals

Project Description

Malignant Hyperthermia (MH) is a genetic metabolic disorder of skeletal muscle triggered by some volatile anesthetics. MH progresses quickly from onset to crisis through rapid release of calcium ions into the sarcoplasm and may cause severe skeletal muscle damage or become fatal. This didactic poster depicts the pathophysiology, symptoms, diagnosis, and etiology of MH. Its main visual challenge was visualizing pathological changes at both molecular and subcellular scales to build up understanding of the causes and consequences of MH. Myofibril sections show calcium signaling changes in addition to changes seen in cell structures. Simplified molecular characters and insets of calcium location provide multiple means of understanding improper calcium signaling in MH.