2021 AMI Online Salon

Endometrial Carcinoma Types I and II

Project Details

  • Entrant Name:  Lydia Gregg
  • Client: JHU Gynecological Pathology
  • Copyright: Johns Hopkins University, 2020
  • Medium/software used: Photoshop, Cinema 4D, Zbrush
  • Final presentation format: 2 page spread book chapter illustration
  • Primary Audience: Gynecological Pathologists

Project Description

The two main images depict the gross features of endometrial carcinoma types I and II. Type I is shown as more diffuse within the uterine wall, with multiple grades in the same lesion, from hyperplasia to high-grade carcinoma. Type II is shown as polypoid with aggressive metastases in the lymph nodes and around the body. The histological insets of type I show progressive crowding and collapse of the glandular endometrium. The insets for type II depict the progressive growth and disorganization of endometrial epithelium into uterine serous carcinoma, which infiltrates into normal tissues and metastasizes. Metastasis shown in this inset relates back to the lymph nodes in the main image of type II. A small inset notes the role of screening in identifying carcinoma mutations.