2021 AMI Online Salon

Cellular Backpacks for Macrophage Immunotherapy

Project Details

  • Entrant Name:  Jer Weann Ang
  • Client:Kelly Cloninger, University of Illinois – Chicago
  • Copyright: Jer Weann Ang, 2021
  • Medium/software used:Pixologic ZBrush, Autodesk 3DSMax, Substance Painter & Designer, Adobe Photoshop & Illustrator
  • Final presentation format:Print, Journal Cover
  • Primary Audience:Biomedical researchers

Project Description

Researchers have recently engineered polymer discoidal particles termed “backpacks” that adhere to macrophages and regulate macrophage phenotypes in tumor microenvironments. These backpacks carry and secrete cytokines that maintain macrophages in their antitumor state, increasing the efficacy of cellular immunotherapies against cancer.This editorial illustration aims to catch the attention of potential readers and prompt them to read the featured research article. The backpack was designed to have an inorganic and futuristic look and feel to emphasize the novel aspect of the engineered technology and was a stylistic interpretation of what would have been simple polymer discs. The emissive lighting on the tubes draws attention to the backpack and highlights the potency of the cytokines stored in the backpack that keep the macrophage in its antitumor state. The macrophage is approaching a group of tumor cells, exhibiting the effectiveness of the macrophage in targeting cancer.