2021 AMI Online Salon

A Common SNP of ABCG2 transporter

Project Details

  • Entrant Name:  Yu-Sin Huang
  • Client: University of Illinois at Chicago
  • Copyright: Yu-Sin Huang, 2021
  • Medium/software used: Visual Molecular Dynamics, RCSB PDB, SWISS-MODEL, 3D Studio Max, Adobe Photoshop, Adobe Illustrator
  • Final presentation format: Two-page spread for a science magazine
  • Primary Audience: Biomedical professionals

Project Description

ABCG2-Q141K is a common type of transmembrane transporter variant. Many anticancer drugs are substrates of ABCG2 protein. Understanding why ABCG2-Q141k affects anticancer drug concentration in plasma may be the key to improving treatment performance in patients with genetic variants. This two-page spread aims to assist the biomedical professional audience in understanding the structure and trafficking defect of ABCG2-Q141K. The combination of 2D and 3D visualization with color-coding magnifies the clarity of information. The single nucleotide was modified in Swiss-Model by using the PDB file as a template to present an accurate structure of the variant.