2021 AMI Online Salon

A Binding Proposal: How is NOD’s proposed bacterial glycan-binding site related to Crohn’s Disease

Project Details

  • Entrant Name:  Martin Shook
  • Client: Faculty Advisor: Derek Ng
  • Copyright: Martin Shook, 2021
  • Medium/software used: Cinema 4D, Adobe Photoshop®, and Adobe Indesign®
  • Final presentation format: Two-page journal Spread
  • Primary Audience: Readers of molecular biology journals, people invested in Crohn’s Disease Research, and general members of the biomolecular community.

Project Description

This two-page journal spread, entitled ‘A Binding Proposal’, reviews recent insights into the molecular structure and function of nucleotide-binding oligomerization domain-containing protein 2 (NOD2). This illustration describes the different domains of the protein and the proposed muramyl dipeptide (MDP) binding site’”correlating mutations in this binding region to Crohn’s Disease. In addition to the NOD2 structure, the protein’s activation and ability to signal NF-kB to translocate into the cell nucleus, resulting in the destruction and inhibition of microorganisms, are summarized. The educational goal of this assignment was to acquire, evaluate, and integrate molecular data from multiple sources (PDB, journal articles, UniProt, and PubChem) in order to craft a compelling visual narrative of a biomolecule.